Effect of ‘pH’ on the rate of asparagine deamidation in polymeric formulations: ‘pH’–rate profile

Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres

Karen K. Fu, Daniel W. Pack, Alexander M. Klibanov et al. · Pharmaceutical Research · 2000 · 751 citations

Natural Sciences, Chemical Engineering, Food Science +13

Chemical Pathways of Peptide Degradation. II. Kinetics of Deamidation of an Asparaginyl Residue in a Model Hexapeptide

Kamlesh C. Patel, Ronald T. Borchardt · Pharmaceutical Research · 1990 · 279 citations

Life Sciences, Biochemistry, Molecular Biology +17

The Effects of Formulation Variables on the Stability of Freeze-Dried Human Growth Hormone

Michael J. Pikal, Karen M. Dellerman, R.M. Riggin · Pharmaceutical Research · 1991 · 273 citations

Pharmacy, Food Science, Pharmaceutics +14

Saturated salt solutions for maintaining specified relative humidities.

H Nyqvist · 1983 · 218 citations

Engineering, Hydrology, Soil-water Relations +6

pH and Osmotic Pressure Inside Biodegradable Microspheres During Erosion1

Anette Brunner, Karsten Mäder, Achim Göpferich · Pharmaceutical Research · 1999 · 210 citations

Natural Sciences, Bioengineering, Erosion Control +10