Concepedia

Deamidation Risk

Deamidation Risk is a biochemical stability metric that quantifies the susceptibility of asparagine and glutamine residues in a protein sequence to undergo deamidation, a non-enzymatic post-translational modification that can alter protein structure, function, and immunogenicity, thereby influencing the developability of biotherapeutic candidates.

7

Publications

310

Citations

19

Authors

9

Institutions

Publications per year

2017–2026

1

Parents

Publications

7

Protein deamidation in biopharmaceutical manufacture: understanding, control and impact

David Gervais · Journal of Chemical Technology & Biotechnology · 2015 · 87 citations · Full text

, , +17

Effect of ‘pH’ on the rate of asparagine deamidation in polymeric formulations: ‘pH’–rate profile

Yuan Song, Richard L. Schowen, Ronald T. Borchardt et al. · Journal of Pharmaceutical Sciences · 2001 · 76 citations

, , +10

Deamidation of asparaginyl residues as a hazard in experimental protein and peptide procedures

James H. McKerrow, Arthur B. Robinson · Analytical Biochemistry · 1971 · 66 citations

, , +13

Multivariate Analysis of the Sequence Dependence of Asparagine Deamidation Rates in Peptides

Andrew A. Kosky, D. Vasumathi, Gayathri Ratnaswamy et al. · Pharmaceutical Research · 2009 · 25 citations

, , +10

l-glutamic and l-aspartic acids—A question of hazard?

John W. Olney · Food and Cosmetics Toxicology · 1975 · 19 citations

, , +4

1–5 of 7

Authors

19

  1. RT
    Ronald T. Borchardt

    University of Kansas, United States

    2 publications · 94 citations

    2

    h-index

  2. GR
    Gayathri Ratnaswamy

    Brandeis University, United States

    1 publications · 25 citations

    1

    h-index

  3. AA
    Andrew A. Kosky

    Amgen (United States), United States

    1 publications · 25 citations

    1

    h-index

  4. DG
    David Gervais

    Defence Science and Technology Laboratory, United Kingdom

    1 publications · 87 citations

    1

    h-index

  5. AM
    Angela M. Gronenborn

    National Institute of Diabetes and Digestive and Kidney Diseases, United States

    1 publications · 19 citations

    1

    h-index

1–5 of 19

Institutions

9

  1. University of Kansas

    Lawrence, United States

    2 h-index

    5 publications

    322 citations

  2. Sunesis (United States)

    South San Francisco, United States

    1 h-index

    1 publications

    25 citations

  3. Office of Legacy Management

    Washington, United States

    1 h-index

    1 publications

    25 citations

  4. Amgen (United States)

    Thousand Oaks, United States

    1 h-index

    2 publications

    50 citations

  5. University of Pittsburgh

    Pittsburgh, United States

    1 h-index

    6 publications

    114 citations

  6. Defence Science and Technology Laboratory

    Salisbury, United Kingdom

    1 h-index

    1 publications

    87 citations

  7. University of California San Diego

    San Diego, United States

    1 h-index

    2 publications

    132 citations

  8. National Audubon Society

    New York, United States

    1 h-index

    1 publications

    19 citations

1–8 of 9

Venues

  1. PubMed

    Repository · 1 publications · 18 citations

    1

    h-index

  2. Food and Cosmetics Toxicology

    1 publications · 19 citations

    1

    h-index

  3. 1

    h-index

  4. Journal of Pharmaceutical Sciences

    1 publications · 76 citations

    1

    h-index

  5. Analytical Biochemistry

    1 publications · 66 citations

    1

    h-index

1–5