Concepedia

Discovery of L-791,943: A potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor

Daniel Guay, Pierre Hamel, Marc Blouin, Christine Brideau, Chi Chung Chan, Nathalie Chauret, Yves Ducharme, Zheng Huang, Mario Girard, Tom R. Jones,

Bioorganic & Medicinal Chemistry Letters · 2002 · 56 citations · 14 references

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PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

Annette Robichaud, Chantal Savoie, Panagiota B. Stamatiou et al. · Neuropharmacology · 2001 · 131 citations

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The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects

P.L. Harbinson, D MacLeod, Richard J. Hawksworth et al. · European Respiratory Journal · 1997 · 121 citations

, , +12

Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret

Annette Robichaud, F.D. Tattersall, Ian W. Rodger · Neuropharmacology · 1999 · 100 citations

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The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4

B. Hughes, D. Howat, H. Lisle et al. · British Journal of Pharmacology · 1996 · 95 citations · Full text

, , +15

Genomic organization of the human phosphodiesterase <i>PDE11A</i> gene

Keizo Yuasa, Yutaka Kanoh, Katsuzumi Okumura et al. · European Journal of Biochemistry · 2001 · 95 citations

, , +11