Concepedia

Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model

Oded Singer, Robert A. Marr, Edward Rockenstein, Leslie Crews, Nicole G. Coufal, Fred H. Gage, Inder M. Verma, Eliezer Masliah

Nature Neuroscience · 2005 · 421 citations · 40 references

DOI

Concepts

References

40

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

Luigi Naldini, Ulrike Blömer, Philippe Gallay et al. · Science · 1996 · 4.9K citations

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A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

Thijn R. Brummelkamp, René Bernards, Reuven Agami · Science · 2002 · 4.3K citations · Full text

, , +16

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

Dominic M. Walsh, Igor Klyubin, Julia V. Fadeeva et al. · Nature · 2002 · 4.3K citations

, , +14

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4.1K citations

, , +17

High-Level Neuronal Expression of Aβ<sub>1–42</sub>in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

Lennart Mucke, Eliezer Masliah, Gui-Qiu Yu et al. · Journal of Neuroscience · 2000 · 1.9K citations · Full text

, , +17