Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer - Concepedia

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Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer

DOI Full Paper Access

129

Citations

16

References

2004

Year

Daniel H. Palmer, Vivien Mautner, Darius F. Mirza, Simon Oliff, Winald R. Gerritsen, Joost R.M. van der Sijp, Stefan G. Hübscher, Gary Reynolds, Sarah Bonney, Ratna Rajaratnam,

Journal of Clinical Oncology

Abstract

Direct intratumoral inoculation of CTL102 to patients with primary and secondary liver cancer is feasible and well tolerated. The high level of nitroreductase expression observed at 1 to 5 x 10(11) virus particles mandates further studies in patients with inoperable tumors who will receive CTL102 and CB1954.

References

	Year	Citations

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