Concepedia

Pharmacological Chaperones Restore Function to MC4R Mutants Responsible for Severe Early-Onset Obesity

Patricia René, Christian Le Gouill, Irina D. Pogozheva, Gary Lee, Henry I. Mosberg, I. Sadaf Farooqi, Kenneth J. Valenzano, Michel Bouvier

Journal of Pharmacology and Experimental Therapeutics · 2010 · 85 citations · 29 references

DOI

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29

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

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Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

I. Sadaf Farooqi, Julia M. Keogh, Giles S.H. Yeo et al. · New England Journal of Medicine · 2003 · 1.8K citations · Full text

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Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

I. Sadaf Farooqi, Giles S.H. Yeo, Julia M. Keogh et al. · Journal of Clinical Investigation · 2000 · 817 citations · Full text

, , +14

Institute of Laboratory Animal Resources.

Thomas L. Wolfle · 1995 · 618 citations

, , +12

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

Jean-Pierre Morello, Ali Salahpour, André Laperrière et al. · Journal of Clinical Investigation · 2000 · 562 citations · Full text

, , +17