Facile One Pot Microwave Assisted Solvent-Free Synthesis of Novel Spiro-Fused Pyran Derivatives via the Three-Component Condensation of Ninhydrin with Malononitrile and Active Methylene Compounds

Abstract

Three-component condensation of ninhydrin, malononitrile, and some nucleophilic reagents in the presence of piperidine under microwave irradiation without solvent afforded the corresponding spiro-fused pyran derivatives. The structures of the products were proved by elemental analyses, IR, 1H NMR and MS spectroscopy.