Concepedia

Active Site Design in a Chemzyme: Development of a Highly Asymmetric and Remarkably Temperature-Independent Catalyst for the Imino Aldol Reaction This work was supported by a grant from UOP Company. We would like to thank Thomas Malloy, Timothy Brandvold and Beth McCulloch for stimulating discussions.

Song Xue, Su Yu, Yonghong Deng, William D. Wulff

PubMed · 2001 · 75 citations · 29 references

DOI

Concepts

Abstract

) should enhance induction. This resulted in asymmetric inductions in excess of 98 % ee at room temperature as well as at 100°C. TMS=trimethylsilyl.

References

29

Catalytic Enantioselective Mannich-Type Reactions Using a Novel Chiral Zirconium Catalyst

Haruro Ishitani, Masaharu Ueno, Shū Kobayashi · Journal of the American Chemical Society · 1997 · 278 citations

, , +9

Enantioselective Addition of Enol Silyl Ethers to Imines Catalyzed by Palladium Complexes:  A Novel Way to Optically Active Acylalanine Derivatives

Emiko Hagiwara, Akio Fujii, Mikiko Sodeoka · Journal of the American Chemical Society · 1998 · 258 citations

, , +11

Catalytic Asymmetric Synthesis of Both Syn- and Anti-β-Amino Alcohols

Shū Kobayashi, Haruro Ishitani, Masaharu Ueno · Journal of the American Chemical Society · 1998 · 251 citations

, , +8

Catalytic, Enantioselective Alkylation of α-Imino Esters Using Late Transition Metal Phosphine Complexes as Catalysts

Dana Ferraris, Brandon Young, Travis Dudding et al. · Journal of the American Chemical Society · 1998 · 239 citations

, , +12

Enantioselective Mannich-Type Reactions Using a Novel Chiral Zirconium Catalyst for the Synthesis of Optically Active β-Amino Acid Derivatives

Haruro Ishitani, Masaharu Ueno, Shū Kobayashi · Journal of the American Chemical Society · 2000 · 228 citations

, , +16