PREDOMINANT EXPRESSION OF T HELPER 2 CYTOKINES AND ALTERED EXPRESSION OF T HELPER 1 CYTOKINES IN LONG-TERM ALLOGRAFT SURVIVAL INDUCED BY INTRATHYMIC IMMUNE MODULATION WITH DONOR CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX PEPTIDES1,2

Abstract

These observations demonstrate that acute graft rejection in this model is associated with the expression of Th1 cytokines, IL-2, and IFN-gamma, whereas long-term survival is associated with predominant expression of Th2 cytokines, IL-4, and IL-10. The expression of IFN-gamma in long-surviving allografts in the absence of IL-2 provides evidence for altered activation of the Th1 response in this intrathymic immune modulation model.