Chronic leptin treatment does not prevent the development of obesity in transgenic mice with brown fat deficiency

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.3K citations

Obesity, Metabolic Syndrome, Knockout Mouse +10

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Jeffrey L. Halaas, K.S. Gajiwala, Margherita Maffei et al. · Science · 1995 · 4.4K citations

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Mary Ann Pelleymounter, Mary Jane Cullen, Mary Baker et al. · Science · 1995 · 4K citations

Nutrition, Genetics, Adipokines +20

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Margherita Maffei, Jeffrey L. Halaas, Éric Ravussin et al. · Nature Medicine · 1995 · 3.7K citations

Obesity, Metabolic Syndrome, Energy Homeostasis +11

Identification and expression cloning of a leptin receptor, OB-R

Louis A. Tartaglia, Marlene Dembski, Xun Weng et al. · Cell · 1995 · 3.5K citations · Full text

Signal Transduction, Molecular Physiology, Hypothalamic Peptide +7