Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis

Abstract

These results support the heretofore unproven occurrence of both local immunoglobulin class switching to IgE and IgE production in the oesophageal mucosa of EO patients. Sensitisation and activation of mast cells involving local IgE may therefore critically contribute to disease pathogenesis.