Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-<i>Rag1null IL2r</i>γ<i>null</i> <i>Ins2Akita</i> Mice

Abstract

NRG-Akita mice provide a model system for validation of the function of human islets and human adult stem cell, embryonic stem cell, or induced pluripotent stem cell-derived beta-cells in the absence or presence of an alloreactive human immune system.