Concepedia

Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin

Donnette Dabydeen, James C. Burnett, Ruoli Bai, Pascal Verdier‐Pinard, Sarah J. H. Hickford, George R. Pettit, John W. Blunt, Murray H. G. Munro, Rick Gussio, Ernest Hamel

Molecular Pharmacology · 2006 · 116 citations · 33 references

DOI

Concepts

References

33

Structure of the αβ tubulin dimer by electron crystallography

Eva Nogales, Sharon G. Wolf, Kenneth H. Downing · Nature · 1998 · 2.1K citations

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Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain

Raimond B. G. Ravelli, Benoı̂t Gigant, Patrick A. Curmi et al. · Nature · 2004 · 1.6K citations

, , +14

Structural basis for the regulation of tubulin by vinblastine

Benoı̂t Gigant, Chunguang Wang, Raimond B. G. Ravelli et al. · Nature · 2005 · 730 citations

, , +11

Halichondrins - antitumor polyether macrolides from a marine sponge

Yoshimasa Hiratå, Daisuke Uemura · Pure and Applied Chemistry · 1986 · 512 citations · Full text

, , +9

The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth

Mary Ann Jordan, Kathryn Kamath, Tapas Manna et al. · Molecular Cancer Therapeutics · 2005 · 494 citations

, , +17