Reduced IFNγ production in response to IL‐12 stimulation and/or reduced IL‐12 production in atopic patients

Abstract

Our results indicated that atopic patients may have some abnormality in the IL-12-IFNgamma loop. It was shown that the elevation in IgE levels in atopic patients may be due to reduced IFNgamma production in response to IL-12 stimulation and/or due to reduced IL-12 production.