A Novel Antiapoptotic Role for α ₁ -Antitrypsin in the Prevention of Pulmonary Emphysema

Abstract

Our findings suggest that inhibition of structural alveolar cell apoptosis by alpha1-antitrypsin represents a novel protective mechanism of the serpin against emphysema. Further elucidation of this mechanism may extend the therapeutic options for emphysema caused by reduced level or loss of function of alpha1-antitrypsin.