Concepedia

A Novel Antiapoptotic Role for α <sub>1</sub> -Antitrypsin in the Prevention of Pulmonary Emphysema

Irina Petrache, Iwona J. Fijałkowska, Lijie Zhen, Terry R. Medler, Emile N. Brown, Pedro E. Cruz, Kang Hyeon Choe, Laimute Taraseviciene‐Stewart, Robertas Scerbavicius, Lee A. Shapiro,

American Journal of Respiratory and Critical Care Medicine · 2006 · 199 citations · 36 references

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Abstract

Our findings suggest that inhibition of structural alveolar cell apoptosis by alpha1-antitrypsin represents a novel protective mechanism of the serpin against emphysema. Further elucidation of this mechanism may extend the therapeutic options for emphysema caused by reduced level or loss of function of alpha1-antitrypsin.

References

36

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

Yasunori Kasahara, Rubin M. Tuder, Laimute Taraseviciene‐Stewart et al. · Journal of Clinical Investigation · 2000 · 1.1K citations · Full text

American Thoracic Society/European Respiratory Society Statement

American Journal of Respiratory and Critical Care Medicine · 2003 · 884 citations

, , +7

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

Tirumalai Rangasamy, Chung Y. Cho, Rajesh K. Thimmulappa et al. · Journal of Clinical Investigation · 2004 · 878 citations

Endothelial Cell Death and Decreased Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 in Emphysema

Yasunori Kasahara, Rubin M. Tuder, Carlyne D. Cool et al. · American Journal of Respiratory and Critical Care Medicine · 2001 · 687 citations

Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

Sergei Zolotukhin, Mark Potter, Irene Zolotukhin et al. · Methods · 2002 · 572 citations

, , +6