Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

Tirumalai Rangasamy, Chung Y. Cho, Rajesh K. Thimmulappa, +7

Journal of Clinical Investigation

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

Tirumalai Rangasamy, Chung Y. Cho, Rajesh K. Thimmulappa, +7

Journal of Clinical Investigation

Disruption of <i>Nrf2</i> enhances susceptibility to severe airway inflammation and asthma in mice

Tirumalai Rangasamy, Jia Guo, Wayne Mitzner, +8

The Journal of Experimental Medicine

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyOxidative Stress +14

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Thomas E. Sussan, Tirumalai Rangasamy, David J. Blake, +13

Proceedings of the National Academy of Sciences

AsthmaLipid PeroxidationImmunologyCell DeathCigarette Smoke-induced Emphysema +18

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

Toshinori Yoshida, Igor Mett, Anil K. Bhunia, +22

Nature Medicine

Tobacco ControlSignal TransductionAllergyInflammatory Lung DiseaseLung Inflammation +9

Glutathione Peroxidase 2, the Major Cigarette Smoke–Inducible Isoform of GPX in Lungs, Is Regulated by Nrf2

Anju Singh, Tirumalai Rangasamy, Rajesh K. Thimmulappa, +6

American Journal of Respiratory Cell and Molecular Biology

Lung InflammationLipid PeroxidationCigarette SmokeSevere EmphysemaRedox Biology +15

Disruption of the Transcription Factor Nrf2 Promotes Pro-Oxidative Dendritic Cells That Stimulate Th2-Like Immunoresponsiveness upon Activation by Ambient Particulate Matter

Marc A. Williams, Tirumalai Rangasamy, Stephen M. Bauer, +7

The Journal of Immunology

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

Tirumalai Rangasamy, Vikas Misra, Lijie Zhen, +3

American Journal of Physiology-Lung Cellular and Molecular Physiology

AsthmaGlobal Gene ExpressionLung InflammationImmunologyCell Death +16

Cell stiffness, contractile stress and the role of extracellular matrix

Steven S. An, Jin‐A Kim, Kwangmi Ahn, +10

Biochemical and Biophysical Research Communications

MechanobiologyEngineeringPhysiologyBiomechanicsCell-matrix Interaction +9

T-Cell Activation under Hypoxic Conditions Enhances IFN-γ Secretion

Jessica Roman, Tirumalai Rangasamy, Jia Guo, +7

American Journal of Respiratory Cell and Molecular Biology

InflammationAutoimmune DiseaseHypoxia-inducible Factor-1alphaT CellsT-regulatory Cell +13