Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice

Irina Petrache, Viswanathan Natarajan, Lijie Zhen, +6

Nature Medicine

InflammationPulmonary Cell ApoptosisAllergyLung InflammationCeramide Upregulation +11

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

Nesrine I. Affara, Brian Ruffell, Terry R. Medler, +13

Cancer Cell

Cancer ImmunosurveillanceOncologySquamous CarcinomasMedicineImmunology +4

α-1 Antitrypsin Inhibits Caspase-3 Activity, Preventing Lung Endothelial Cell Apoptosis

Irina Petrache, Iwona J. Fijałkowska, Terry R. Medler, +6

American Journal Of Pathology

InflammationInflammatory Lung DiseaseLung InflammationMedicineApoptosis +8

A Novel Antiapoptotic Role for α ₁ -Antitrypsin in the Prevention of Pulmonary Emphysema

Irina Petrache, Iwona J. Fijałkowska, Lijie Zhen, +13

American Journal of Respiratory and Critical Care Medicine

Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy

Terry R. Medler, Dhaarini Murugan, Wesley Horton, +9

Cancer Cell

Complement SystemCancer ImmunosurveillanceT-regulatory CellImmunologyImmune Checkpoint Inhibitor +6

Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer

Andrew J. Gunderson, Venkatesh Rajamanickam, Cynthia Bui, +17

OncoImmunology

Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide

Irina Petrache, Terry R. Medler, Amy Richter, +10

American Journal of Physiology-Lung Cellular and Molecular Physiology

Superoxide Dismutase ProtectsLung InflammationLipid PeroxidationApoptosisImmunology +15

Immune Response to Cancer Therapy: Mounting an Effective Antitumor Response and Mechanisms of Resistance

Terry R. Medler, Tiziana Cotechini, Lisa M. Coussens

Trends in cancer

Cancer TherapyImmune EvasionTumor ImmunologyCancer ImmunosurveillanceMedicine +12

Apoptotic Sphingolipid Signaling by Ceramides in Lung Endothelial Cells

Terry R. Medler, Daniela N. Petrusca, Patty J. Lee, +7

American Journal of Respiratory Cell and Molecular Biology

Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma

Jason R. Baird, R. Bryan Bell, Victoria Troesch, +12

Cancer Research