The Hedgehog signalling pathway and its prognostic impact in human gliomas

Abstract

These results provide convincing evidence that the Shh-Ptch1-Gli1 signalling pathway is activated in human gliomas and correlates with clinicopathologic features as well as with prognostic parameters of the tumours. Hedgehog signalling pathway may therefore play an important role in the malignant potential and survival of gliomas.