Concepedia

Biosynthesis of conjugatable saccharidic moieties of GM2 and GM3 gangliosides by engineered E. coli

Sébastien Fort, Lémonia Birikaki, Marie‐Pierre Dubois, Tatiana Antoine, Eric Samain, Hugues Driguez

Chemical Communications · 2005 · 44 citations · 10 references

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Abstract

Oligosaccharidic moieties of GM(2) and GM(3) gangliosides bearing an allyl or a propargyl aglycon, are efficiently biosynthesized on the gram scale by growing metabolically engineered Escherichia coli cells in the presence of the corresponding lactoside acceptors and sialic acid.

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A highly diastereoselective, practical synthesis of allyl, propargyl 2,3,4,6-tetra-O-acetyl-β-d-gluco, β-d-galactopyranosides and allyl, propargyl heptaacetyl-β-d-lactosides

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