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Publication | Open Access

The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) Enhances the Radiation Responsiveness of Lung and Colorectal Tumor Xenografts

DOIFull Paper Access

51

Citations

40

References

2009

Year

Aoife M. Shannon, Brian A. Telfer, Paul D. Smith, Muhammed Babur, Armelle Logié, Robert W. Wilkinson, Camille Debray, Ian J. Stratford, Kaye J. Williams, Stephen R. Wedge
Clinical Cancer Research

Abstract

These data provide support for the clinical development of AZD6244 in combination with radiotherapy and indicate a potential role for AZD6244 in inhibiting the tumor hypoxia response.

References

YearCitations

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