Targeting the AKT/GSK3β/Cyclin D1/Cdk4 Survival Signaling Pathway for Eradication of Tumor Radioresistance Acquired by Fractionated Radiotherapy

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1–dependent cellular transformation

Jodi R. Alt, John L. Cleveland, Mark Hannink et al. · Genes & Development · 2000 · 537 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

Lin Yang, Han C. Dan, Mei Sun et al. · Cancer Research · 2004 · 423 citations

Medicine, Oncology, Pharmacology +17

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

Lana Bozulic, Banu Sürücü, Debby Hynx et al. · Molecular Cell · 2008 · 391 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.

Anjali Gupta, W. Gillies McKenna, Charles N. Weber et al. · PubMed · 2002 · 348 citations

Medicine, Oncology, Radiation Oncology +17

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells

Huifang Li, Jung-Sik Kim, Todd Waldman · Radiation Oncology · 2009 · 192 citations · Full text

Medicine, Oncology, Radiation Oncology +17