Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.

Anjali Gupta, W. Gillies McKenna, Charles N. Weber, Michael D. Feldman, Jeffrey D. Goldsmith, Rosemarie Mick, Mitchell Machtay, David I. Rosenthal, Vincent J. Bakanauskas, George J. Cerniglia,

PubMed · 2002 · 348 citations · 30 references

Abstract

Evaluation of PI3K activation by Akt phosphorylation might be a prognostic marker for response to therapy, and PI3K could be a useful target for therapy. These results also suggest that signaling from EGFR to PI3K can lead to radioresistance.

References

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