PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

Lana Bozulic, Banu Sürücü, Debby Hynx, +1

Molecular Cell

Genome InstabilityCell RegulationGeneticsApoptosisDna Replication +7

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

Hong‐wa Yung, Stefania Calabrese, Debby Hynx, +4

American Journal Of Pathology

InfertilityDevelopmental BiologyPlacental DevelopmentPregnancyMaternal Health +9

Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies

Bettina Dümmler, Oliver Tschopp, Debby Hynx, +3

Molecular and Cellular Biology

Single IsoformInsulin SignalingIsoform RedundancySignaling PathwayReceptor Tyrosine Kinase +17

Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes

Gongda Xue, David F. Restuccia, Qiang Lan, +4

Cancer Discovery

NDR Functions as a Physiological YAP1 Kinase in the Intestinal Epithelium

Lei Zhang, Fengyuan Tang, Luigi Terracciano, +7

Current Biology

Protein FunctionMolecular PhysiologySignal TransductionSignaling PathwayReceptor Tyrosine Kinase +8

MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas

Michal Grzmil, Roland M. Huber, Stephan Frank, +5

Journal of Clinical Investigation

Neuro-oncologySignaling PathwayGliomaMtorc1 Inhibitor RapamycinMedicine +11

The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility

Fengyuan Tang, Jason Gill, Xenia Ficht, +14

Science Signaling

Ablation of the Kinase NDR1 Predisposes Mice to the Development of T Cell Lymphoma

Hauke Cornils, Mario Stegert, Alexander Hergovich, +4

Science Signaling

Lymphocyte DevelopmentApoptosisImmunologyCell DeathDefective Apoptosis Contributes +14

In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis

Banu Sürücü, Lana Bozulic, Debby Hynx, +2

Journal of Biological Chemistry

Cell DeathMolecular BiologyDna-dependent Protein KinaseFull ActivationTumor Biology +16

Acyl Coenzyme A Thioesterase Them5/Acot15 Is Involved in Cardiolipin Remodeling and Fatty Liver Development

Elena Zhuravleva, H. Gut, Debby Hynx, +8

Molecular and Cellular Biology

Molecular BiologyMitochondrial BiologyFatty Liver DiseaseRedox BiologyCardiolipin Remodeling +19