Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.

A Y Chen, C. Yu, Barbara Gatto et al. · Proceedings of the National Academy of Sciences · 1993 · 273 citations

Medicine, Pharmacology, Cancer Pharmacology +12

Tyrosine Kinase Inhibitors. 9. Synthesis and Evaluation of Fused Tricyclic Quinazoline Analogues as ATP Site Inhibitors of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor

Gordon W. Rewcastle, Brian D. Palmer, Alexander J. Bridges et al. · Journal of Medicinal Chemistry · 1996 · 149 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

A new mammalian DNA topoisomerase I poison Hoechst 33342: cytotoxicity and drug resistance in human cell cultures.

Allan Y. Chen, Chiang Yu, Annette L. Bodley et al. · PubMed · 1993 · 148 citations

Life Sciences, Cell Biology, Molecular Biology +15

Metal-halogen exchange of bromoindoles. A route to substituted indoles

Mikel P. Moyer, John F. Shiurba, Henry Rapoport · The Journal of Organic Chemistry · 1986 · 146 citations

Natural Sciences, Chemistry, Analytical Chemistry +11

Synthesis and Evaluation of Terbenzimidazoles as Topoisomerase I Inhibitors

Qun Sun, Barbara Gatto, Chiang Yu et al. · Journal of Medicinal Chemistry · 1995 · 67 citations

Medicine, Medicinal Chemistry, Pharmacology +7