A Y Chen

DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors.

A Y Chen, C. Yu, Barbara Gatto et al. · Proceedings of the National Academy of Sciences · 1993 · 272 citations · Full text

Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives.

A Y Chen, Paul Okunieff, Yves Pommier et al. · PubMed · 1997 · 81 citations

Camptothecin Derivatives, Radiation Therapy, Radiation Biology +15

Design of antineoplastic agents on the basis of the 2-phenylnaphthalene-type structural pattern. 2. Synthesis and biological activity studies of benzo[b]naphtho[2,3-d]furan-6,11-dione derivatives

C. C. Cheng, Qing Dong, D F Liu et al. · Journal of Medicinal Chemistry · 1993 · 56 citations

Sequential addition of temperature-sensitive missense mutations into the PB2 gene of influenza A transfectant viruses can effect an increase in temperature sensitivity and attenuation and permits the rational design of a genetically engineered live influenza A virus vaccine

Kanta Subbarao, E J Park, C M Lawson et al. · Journal of Virology · 1995 · 52 citations · Full text

Engineering, Reverse Genetics, Synthetic Virology +17

Human immunodeficiency virus type 1 (HIV-1) inhibition, DNA-binding, RNA-binding, and ribosome inactivation activities in the N-terminal segments of the plant anti-HIV protein GAP31.

Sylvia Lee‐Huang, H F Kung, Paul L. Huang et al. · Proceedings of the National Academy of Sciences · 1994 · 49 citations · Full text

Bioorganic Chemistry, Immunology, Molecular Biology +22