Concepedia

Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus

Sebastian Dolff, Wayel H. Abdulahad, Johanna Westra, Berber Doornbos‐van der Meer, Pieter C. Limburg, Cees G. M. Kallenberg, Marc Bijl

Arthritis Research & Therapy · 2011 · 129 citations · 21 references

DOI Full text

Open access

Abstract

This study demonstrates an increased proportion of IL-21+ T-cells in SLE patients correlating with the proportion of IL-17+ T-cells. This suggests a pivotal role of IL-21 in the pathogenesis of SLE.

References

21

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Liang Zhou, Ivaylo I. Ivanov, Rosanne Spolski et al. · Nature Immunology · 2007 · 2.1K citations

Inflammation, Cytokine, Autoimmune Disease +9

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Thomas Korn, Estelle Bettelli, Wenda Gao et al. · Nature · 2007 · 1.8K citations · Full text

Inflammation, Cytokine, Immunology +9

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

Julia Parrish-Novak, Stacey R. Dillon, Andrew Nelson et al. · Nature · 2000 · 1.2K citations

Inflammation, Allergy, Autoimmune Disease +13

A Critical Role for IL-21 in Regulating Immunoglobulin Production

Katsutoshi Ozaki, Rosanne Spolski, Carl G. Feng et al. · Science · 2002 · 956 citations

Primary Immunodeficiency, Inflammation, Regulating Immunoglobulin Production +14

Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function

Rong Zeng, Rosanne Spolski, Steven E. Finkelstein et al. · The Journal of Experimental Medicine · 2005 · 699 citations · Full text