Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

Obesity, Metabolic Syndrome, Energy Homeostasis +12

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Wei Fan, Bruce A. Boston, Robert A. Kesterson et al. · Nature · 1997 · 1.9K citations

Obesity, Metabolic Syndrome, Energy Homeostasis +12

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

Dongsi Lu, Derril H. Willard, Indravadan R. Patel et al. · Nature · 1994 · 1.1K citations

Signal Transduction, G Protein-coupled Receptor, Medicine +8

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

Donald J. Marsh, Gunther Hollopeter, Dennis Huszar et al. · Nature Genetics · 1999 · 545 citations

Neuropeptides, Appetite Control, Medicine +9

A role for the melanocortin 4 receptor in sexual function

Lex H.T. Van der Ploeg, William J. Martin, Andrew D. Howard et al. · Proceedings of the National Academy of Sciences · 2002 · 298 citations · Full text

Erectile Dysfunction, Food Intake, Reproductive Biology +22