Angewandte Chemie International Edition · 2011 · 261 citations · 43 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisRetrosynthetic AnalysisScaffold DiversificationStereochemical OptimizationAsymmetric Heterocycle SynthesisDiversity-oriented Stereoselective SynthesisEnantioselective SynthesisScaffold SynthesisScaffold-based Library SynthesisSpirocyclic Scaffold DiversificationSpirocyclic ScaffoldsSpiroheterocycle Synthesis
A-spiro-ing: The title reaction of α-isothiocyanato imides and methyleneindolinones has been realized for the first time using 1 as the catalyst. This newly developed synthetic method provides a simple, efficient, and environmentally friendly way to access, in an enantioselective manner, densely functionalized spirooxindoles having three contiguous stereogenic centers.
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