Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Molecular Pharmacology, µ-Opioid-receptor Gene, Pain Disorders +15

Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia

Ichiro Sora, Nobuyuki Takahashi, Masahiko Funada et al. · Proceedings of the National Academy of Sciences · 1997 · 527 citations · Full text

Pain Disorders, Acute Pain, Pain Medicine +21

Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice

Yanxin Zhu, Michael A. King, Alwin G. Schuller et al. · Neuron · 1999 · 431 citations · Full text

Opioid Epidemic, Morphine Tolerance, Pain Medicine +17

Disruption of the kappa -opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa -agonist U-50,488H and attenuates morphine withdrawal

Frédéric Simonin · The EMBO Journal · 1998 · 413 citations

Inflammation, Chemical Visceral Pain, Health Sciences +12

μ Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality

Horace H. Loh, Hsien-Ching Liu, Antonella Cavalli et al. · Molecular Brain Research · 1998 · 338 citations

Opioid Epidemic, Molecular Pharmacology, Health Sciences +15