Concepedia

Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones

Sylvie Ducki, Grant Mackenzie, Ben Greedy, Simon J. Armitage, Jérémie Fournier Dit Chabert, Elizabeth Bennett, Jim Nettles, James P. Snyder, Nicholas J. Lawrence

Bioorganic & Medicinal Chemistry · 2009 · 81 citations · 24 references

DOI

Concepts

References

24

Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function

Garrett M. Morris, David S. Goodsell, Robert S. Halliday et al. · Journal of Computational Chemistry · 1998 · 10.8K citations

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Structure of the αβ tubulin dimer by electron crystallography

Eva Nogales, Sharon G. Wolf, Kenneth H. Downing · Nature · 1998 · 2.1K citations

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Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain

Raimond B. G. Ravelli, Benoı̂t Gigant, Patrick A. Curmi et al. · Nature · 2004 · 1.6K citations

, , +14

Refined structure of αβ-tubulin at 3.5 Å resolution 1 1Edited by I. A. Wilson

Jan Löwe, Huilin Li, Kenneth H. Downing et al. · Journal of Molecular Biology · 2001 · 1.2K citations

, , +10

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George R. Pettit, Sheo B. Singh, Ernest Hamel et al. · Cellular and Molecular Life Sciences · 1989 · 789 citations

, , +11