Concepedia

Synthesis of 3-(2-N,N-diethylaminoethoxy)indoles as potential 5-HT6 receptor ligands

Karolin Alex, Nicolle Schwarz, Vivek Khedkar, Iliyas Ali Sayyed, Annegret Tillack, Dirk Michalik, Jörg Holenz, José Luis Dı́az, Matthias Beller

Organic & Biomolecular Chemistry · 2008 · 33 citations · 38 references

DOI

Concepts

Abstract

The synthesis of new pharmaceutically interesting 3-(2-N,N-diethylaminoethoxy)indole derivatives is described. Starting from 3-silyloxy-2-methylindoles, deprotection and in situ aminoalkylation provided 3-(2-N,N-diethylaminoethoxy)indoles in good yield. Further sulfonylation of these novel indoles gave access to potential 5-HT(6) receptor ligands.

References

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