p53 Suppression of Arsenite-Induced Mitotic Catastrophe Is Mediated by p21CIP1/WAF1

Arsenic in Drinking Water

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p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

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Life Sciences, Cell Biology, Molecular Biology +17

The p53 functional circuit

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Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-xL

Charles Perkins, Caryn N. Kim, Guofu Fang et al. · Blood · 2000 · 233 citations

Medicine, Cancer Biology, Oncology +12

The late increase in intracellular free radical oxygen species during apoptosis is associated with cytochrome c release, caspase activation, and mitochondrial dysfunction

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