IL-17A stimulates the production of inflammatory mediators via Erk1/2, p38 MAPK, PI3K/Akt, and NF-κB pathways in ARPE-19 cells.

Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Laurie E. Harrington, Robin D. Hatton, Paul R. Mangan et al. · Nature Immunology · 2005 · 4.6K citations

Lymphocyte Development, Immune Cell Development, Adaptive Immune System +10

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Heon Park, Zhaoxia Li, Xuexian O. Yang et al. · Nature Immunology · 2005 · 4.2K citations · Full text

Inflammation, Autoimmune Disease, Tissue Inflammation +11

Development, cytokine profile and function of human interleukin 17–producing helper T cells

Nicholas J. Wilson, Katia Boniface, Jason R. Chan et al. · Nature Immunology · 2007 · 2K citations

Inflammation, Cytokine, Immune Cell Development +10

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1

Ahjoku Amadi‐Obi, Cheng‐Rong Yu, Xuebin Liu et al. · Nature Medicine · 2007 · 842 citations

Inflammation, Cytokine, Allergy +9

IL-17: prototype member of an emerging cytokine family

Sudeepta Aggarwal, Austin Gurney · Journal of Leukocyte Biology · 2002 · 589 citations · Full text

Inflammation, Cytokine, New Family +11