AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Masamichi Muramatsu, Kazuo Kinoshita, Sidonia Fagarasan et al. · Cell · 2000 · 3.4K citations

Natural Sciences, Genetics, Rna Biology +7

Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2)

Patrick Revy, Taro Muto, Yves Lévy et al. · Cell · 2000 · 1.6K citations · Full text

Mendelian Disorder, Autoimmune Disease, Genetic Disorder +8

Specific Expression of Activation-induced Cytidine Deaminase (AID), a Novel Member of the RNA-editing Deaminase Family in Germinal Center B Cells

Masamichi Muramatsu, V.S. Sankaranand, Shrikant Anant et al. · Journal of Biological Chemistry · 1999 · 1.1K citations · Full text

An Anthropoid-Specific Locus of Orphan C to U RNA-Editing Enzymes on Chromosome 22

Adam Jarmuz, Ann Chester, Jayne Bayliss et al. · Genomics · 2002 · 696 citations

Anthropoid-specific Locus, Chromatin, Rna Processing +14

AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching

Simone Petersen, Rafael Casellas, Bernardo Reina‐San‐Martin et al. · Nature · 2001 · 494 citations · Full text

Genetic Disorder, Nbs1/γ-h2ax Focus Formation, Genetics +6