Concepedia

Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents

Roberto Calcedo, Hiroki Morizono, Lili Wang, Robert McCarter, Jianping He, David Jones, Mark L. Batshaw, James M. Wilson

Clinical and Vaccine Immunology · 2011 · 332 citations · 18 references

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Concepts

Abstract

Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer. NAb titers to AAV serotype 2 (AAV2) and AAV8 in human subjects (0 to 18 years) were studied. NAb prevalence is moderate at birth, decreases markedly from 7 to 11 months, and then progressively increases through childhood and adolescence.

References

18

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

Guangping Gao, Mauricio R. Alvira, Lili Wang et al. · Proceedings of the National Academy of Sciences · 2002 · 1.5K citations · Full text

, , +15

Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors

Sylvie Boutin, Virginie Monteilhet, P. Véron et al. · Human Gene Therapy · 2010 · 947 citations

, , +15

Worldwide Epidemiology of Neutralizing Antibodies to Adeno‐Associated Viruses

Roberto Calcedo, Luk H. Vandenberghe, Guangping Gao et al. · The Journal of Infectious Diseases · 2009 · 792 citations · Full text

, , +14

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

Haiyan Jiang, Linda B. Couto, Susannah Patarroyo‐White et al. · Blood · 2006 · 320 citations · Full text

, , +17

Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models

Andrew M. Davidoff, John T. Gray, Catherine Y. Ng et al. · Molecular Therapy · 2005 · 216 citations · Full text

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