A LIPID METABOLIC DISEASE —“MEMBRANOUS LIPODYSTROPHY”— AN AUTOPSY CASE DEMONSTRATING NUMEROUS PECULIAR MEMBRANE‐STRUCTURES COMPOSED OF COMPOUND LIPID IN BONE AND BONE MARROW AND VARIOUS ADIPOSE TISSUES

Abstract

An autopsy case of a 38‐year‐old man demonstrating numerous peculiar membrane‐structures composed of compound lipid in the meta‐physis and marrow of long bones and various organs, where physiological hyperplasia ex vacuo of adipose tissue has occurred remarkably, is reported. The membranous structure was not observed in the brain while sudanophilic leucodystrophy was prominent. The cause of this case is assumed to be an abnormality in the process of differentiation and proliferation of mesenchymal cell to fat cell in adult age, in which the lipid is combined with mucopolysaccharide in the ground substance of connective tissue, resulting in formation of peculiar membranous structure. ACTA PATH. JAP. 23: 539–558, 1973.