Concepedia

AOPPs Induce MCP-1 Expression by Increasing ROS-Mediated Activation of the NF-κB Pathway in Rat Mesangial Cells: Inhibition by Sesquiterpene Lactones

Jiancheng Wang, Yan Zhao, Si‐Jia Chen, Jing Long, Qianqian Jia, Jiadai Zhai, Quan Zhang, Yue Chen, Haibo Long

Cellular Physiology and Biochemistry · 2013 · 28 citations · 16 references

DOIFull text

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Abstract

AOPPs induce MCP-1 expression by activating the ROS/NF-κB pathway and can be inhibited by SLs. These findings may provide a novel approach to treat inflammatory and immune renal diseases, including diabetic nephropathy.

References

16

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The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase

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