Concepedia

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase

Benjamin H. Kwok, Brian D. Koh, MacKevin Ndubuisi, Mikael Elofsson, Craig M. Crews

Chemistry & Biology · 2001 · 512 citations · 33 references

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References

33

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Frank Mercurio, Hengyi Zhu, Brion W. Murray et al. · Science · 1997 · 2K citations

, , +15

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

Min-Jean Yin, Yumi Yamamoto, Richard B. Gaynor · Nature · 1998 · 1.6K citations

, , +14

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase

Antonio Rossi, Pankaj Kapahi, Gioacchino Natoli et al. · Nature · 2000 · 1.3K citations

, , +15

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

John Woronicz, Xiong Gao, Zhaodan Cao et al. · Science · 1997 · 1.2K citations

, , +16

Identification and Characterization of an IκB Kinase

Catherine H. Régnier, Ho Yeong Song, Xiong Gao et al. · Cell · 1997 · 1.2K citations · Full text

, , +10