Pharmaceutica Analytica Acta · 2012 · 24 citations · 20 references
PharmacyMedicinal ChemistryPharmacologyDrug DeliveryInflammationNanoparticle Drug DeliveryAnti-inflammatory PharmacologyInflammatory SignalingNanomedicineAnti-inflammatory ActivityAnti-inflammatory Drug MechanismsAnti-inflammatory Natural ProductsAnti-inflammatory ResponseProtein Expression Levels
Mechanistically, both curcumin and celecoxib utilize a different pathway to inhibit COX-2. It is believed that curcumin down-regulates COX-2 mRNA and protein levels, while celecoxib inhibits COX-2 activity directly by binding to its active site. Hence, the synergistic use of these drugs could augment the anti-inflammatory activity.
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