Concepedia

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

Jin‐Mi Heo, Alban Ordureau, João A. Paulo, Jesse Rinehart, J. Wade Harper

Molecular Cell · 2015 · 882 citations · 37 references

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References

37

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text

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IKKε and TBK1 are essential components of the IRF3 signaling pathway

Katherine A. Fitzgerald, Sarah M. McWhirter, Daniel C. Rowe et al. · Nature Immunology · 2003 · 2.7K citations

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TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Jemeen Sreedharan, Ian P. Blair, Vineeta B. Tripathi et al. · Science · 2008 · 2.6K citations · Full text

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Ubiquitin is phosphorylated by PINK1 to activate parkin

Fumika Koyano, Kei Okatsu, Hidetaka Kosako et al. · Nature · 2014 · 1.5K citations

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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Lesley A. Kane, Michael Lazarou, Adam I. Fogel et al. · The Journal of Cell Biology · 2014 · 1.3K citations · Full text

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