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The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

Peter T. Sage, Alison M. Paterson, Scott B. Lovitch, Arlene H. Sharpe

Immunity · 2014 · 414 citations · 34 references

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34

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

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CTLA-4 Control over Foxp3 <sup>+</sup> Regulatory T Cell Function

Kajsa Wing, Yasushi Onishi, Paz Prieto-Martin et al. · Science · 2008 · 2.9K citations

, , +17

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

Omar Qureshi, Yong Zheng, Kyoko Nakamura et al. · Science · 2011 · 1.8K citations · Full text

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Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

Manish J. Butte, Mary Keir, Theresa B. Phamduy et al. · Immunity · 2007 · 1.7K citations · Full text

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Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

Robert J. Johnston, Amanda C. Poholek, Daniel DiToro et al. · Science · 2009 · 1.6K citations

, , +17