Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

Yan Shu, Steven A. Sheardown, Chaline Brown et al. · Journal of Clinical Investigation · 2007 · 958 citations · Full text

Medicine, Endocrinology, Pharmacology +13

Mapping cis- and trans-regulatory effects across multiple tissues in twins

Elin Grundberg, Kerrin S. Small, Åsa K. Hedman et al. · Nature Genetics · 2012 · 787 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

Desheng Wang, Johan W. Jonker, Yukio Kato et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 442 citations

Pharmacy, Endocrinology, Pharmacology +17

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

Matthijs L. Becker, Loes E. Visser, Ron H. N. van Schaik et al. · Diabetes · 2009 · 287 citations · Full text

Medicine, Endocrinology, Pharmacology +17

Reduction of metformin renal tubular secretion by cimetidine in man.

A. Somogyi, Creina S. Stockley, Julie Keal et al. · British Journal of Clinical Pharmacology · 1987 · 283 citations

Pharmacy, Pharmacokinetics, Pharmacology +17