Concepedia

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

César Sánchez, Aaroa P. Salas, Alfredo F. Braña, Martina Palomino‐Schätzlein, Antonio Pineda‐Lucena, Rodrigo J. Carbajo, Cármen Méndez, Francisco Morís, José A. Salas

Chemical Communications · 2009 · 63 citations · 11 references

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Abstract

We report the generation of novel glycosylated indolocarbazoles by combinatorial biosynthesis, and the identification of two novel potent and selective compounds inhibitors of JAK2 and Ikkb kinases.

References

11

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

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IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway

Dung‐Fang Lee, Hsu-Ping Kuo, Chun‐Te Chen et al. · Cell · 2007 · 630 citations · Full text

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Combinatorial biosynthesis of antitumor indolocarbazole compounds

César Sánchez, Alfredo F. Braña, Aaroa P. Salas et al. · Proceedings of the National Academy of Sciences · 2004 · 246 citations · Full text

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The Biosynthetic Gene Cluster for the Antitumor Rebeccamycin

César Sánchez, Igor A. Butovich, Alfredo F. Braña et al. · Chemistry & Biology · 2002 · 218 citations · Full text

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Cloning of the Staurosporine Biosynthetic Gene Cluster from Streptomyces sp. TP-A0274 and Its Heterologous Expression in Streptomyces lividans.

Hiroyasu Onaka, SHIN-ICHI TANIFGUCHI, Yasuhiro Igarashi et al. · The Journal of Antibiotics · 2002 · 131 citations · Full text

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