Concepedia

A computational tool for the simulation and optimization of microbial strains accounting integrated metabolic/regulatory information

Paulo Vilaça, Isabel Rocha, Miguel Rocha

Biosystems · 2010 · 19 citations · 22 references

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References

22

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0

Jan Schellenberger, Richard Que, Ronan M. T. Fleming et al. · Nature Protocols · 2011 · 1.9K citations · Full text

, , +17

Analysis of optimality in natural and perturbed metabolic networks

Daniel Segrè, Dennis Vitkup, George M. Church · Proceedings of the National Academy of Sciences · 2002 · 1.4K citations

, , +15

Optknock: A bilevel programming framework for identifying gene knockout strategies for microbial strain optimization

Anthony P. Burgard, Priti Pharkya, Costas D. Maranas · Biotechnology and Bioengineering · 2003 · 1.3K citations

, , +17

An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)

Jennifer L. Reed, Thuy D. Vo, Christophe H. Schilling et al. · Genome biology · 2003 · 1K citations · Full text

, , +9

Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth

Rafael U. Ibarra, Jeremy S. Edwards, Bernhard Ø. Palsson · Nature · 2002 · 879 citations

, , +13