Concepedia

Strain Design Optimization

Strain Design Optimization is a computational framework in genome-scale metabolic modeling that identifies optimal genetic and regulatory modifications to achieve desired metabolic phenotypes while maximizing pathway efficiency and organismal fitness.

88

Publications

4K

Citations

433

Authors

164

Institutions

Publications per year

2017–2026

45

Parents

Publications

88

Predicting metabolic engineering knockout strategies for chemical production: accounting for competing pathways

Naama Tepper, Tomer Shlomi · Bioinformatics · 2009 · 247 citations · Full text

, , +17

OptORF: Optimal metabolic and regulatory perturbations for metabolic engineering of microbial strains

Joonhoon Kim, Jennifer L. Reed · BMC Systems Biology · 2010 · 217 citations · Full text

, , +17

Lessons from Two Design–Build–Test–Learn Cycles of Dodecanol Production in <i>Escherichia coli</i> Aided by Machine Learning

Paul H. Opgenorth, Zak Costello, Takuya Okada et al. · ACS Synthetic Biology · 2019 · 162 citations · Full text

, , +17

Unique attributes of cyanobacterial metabolism revealed by improved genome-scale metabolic modeling and essential gene analysis

Jared T. Broddrick, Benjamin E. Rubin, David Welkie et al. · Proceedings of the National Academy of Sciences · 2016 · 134 citations · Full text

, , +17

k-OptForce: Integrating Kinetics with Flux Balance Analysis for Strain Design

Anupam Chowdhury, Ali R. Zomorrodi, Costas D. Maranas · PLoS Computational Biology · 2014 · 131 citations · Full text

, , +17

1–5 of 88

Authors

433

  1. DL
    Dong‐Yup Lee

    Bioprocessing Technology Institute, Singapore

    5 publications · 108 citations

    5

    h-index

  2. ML
    Meiyappan Lakshmanan

    Bioprocessing Technology Institute, Singapore

    4 publications · 96 citations

    4

    h-index

  3. MR
    Miguel Rocha

    University of Minho, Portugal

    4 publications · 180 citations

    4

    h-index

  4. GN
    Giuseppe Nicosia

    University of Catania, Italy

    3 publications · 106 citations

    3

    h-index

  5. JK
    Joonhoon Kim

    Pacific Northwest National Laboratory, United States

    3 publications · 339 citations

    3

    h-index

1–5 of 433

Institutions

164

  1. Bioprocessing Technology Institute

    Singapore, Singapore

    5 h-index

    10 publications

    224 citations

  2. Agency for Science, Technology and Research

    Singapore, Singapore

    5 h-index

    10 publications

    224 citations

  3. National University of Singapore

    Singapore, Singapore

    5 h-index

    6 publications

    128 citations

  4. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    6 publications

    137 citations

  5. Great Lakes Bioenergy Research Center

    Madison, United States

    4 h-index

    13 publications

    918 citations

  6. University of California San Diego

    San Diego, United States

    4 h-index

    23 publications

    2.1K citations

  7. University of Minho

    Braga, Portugal

    4 h-index

    14 publications

    859 citations

  8. University of Wisconsin–Madison

    Madison, United States

    4 h-index

    13 publications

    918 citations

1–8 of 164

Venues

  1. Bioinformatics

    8 publications · 434 citations

    8

    h-index

  2. Metabolic Engineering

    7 publications · 381 citations

    7

    h-index

  3. Biotechnology and Bioengineering

    6 publications · 256 citations

    6

    h-index

  4. ACS Synthetic Biology

    6 publications · 321 citations

    6

    h-index

  5. PLoS Computational Biology

    5 publications · 309 citations

    5

    h-index

1–5