Proceedings of the National Academy of Sciences · 2013 · 59 citations · 33 references
Life SciencesDevelopmental BiologyMolecular BiologyDevelopmental NeuroscienceEpigeneticsGene ExpressionChromatinDevelopmental EpigeneticsEpigenetic Regulation In DevelopmentHistone ModificationsNeural DevelopmentNeuronal MigrationAtp-dependent Chromatin RemodelingChromatin RemodelingChromatin Remodeling During DevelopmentEpigenetic Gene RegulationNeuronal Epigenetic RegulationNitric OxideNitric Oxide BiologyRadial Migration
Dynamic epigenetic modifications play a key role in mediating the expression of genes required for neuronal development. We previously identified nitric oxide (NO) as a signaling molecule that mediates S-nitrosylation of histone deacetylase 2 (HDAC2) and epigenetic changes in neurons. Here, we show that HDAC2 nitrosylation regulates neuronal radial migration during cortical development. Bead-array analysis performed in the developing cortex revealed that brahma (Brm), a subunit of the ATP-dependent chromatin-remodeling complex BRG/brahma-associated factor, is one of the genes regulated by S-nitrosylation of HDAC2. In the cortex, expression of a mutant form of HDAC2 that cannot be nitrosylated dramatically inhibits Brm expression. Our study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons.
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Targeted disruption of the neuronal nitric oxide synthase gene
Paul L. Huang, Ted M. Dawson, David S. Bredt et al. · Cell · 1993 · 1.3K citations
Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase
Randy J. Nelson, Gregory E. Demas, Paul L. Huang et al. · Nature · 1995 · 603 citations