Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

Steven Lin, Brett T. Staahl, Ravi Alla, +1

eLife

An Essential Switch in Subunit Composition of a Chromatin Remodeling Complex during Neural Development

Julie Lessard, Jiang Wu, Jeffrey A. Ranish, +6

Neuron

ChromatinSubunit CompositionDevelopmental BiologyChromatin StructureChromatin Remodeling +8

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

Andrew S. Yoo, Brett T. Staahl, Lei Chen, +1

Nature

ChromatinDevelopmental BiologyChromatin RemodelingSmall RnaMicrorna-mediated Switching +3

An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency

Lena Ho, Jehnna L. Ronan, Jiang Wu, +7

Proceedings of the National Academy of Sciences

GeneticsStem Cell BiologyCell SpecializationEpigeneticsMouse Es Cells +17

CasX enzymes comprise a distinct family of RNA-guided genome editors

Junjie Liu, N. S. Orlova, Benjamin L. Oakes, +15

Nature

Distinct FamilyNatural SciencesRna BiologyMolecular BiologyDna Replication +7

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes

Brett T. Staahl, Madhurima Benekareddy, Claire Coulon-Bainier, +7

Nature Biotechnology

EngineeringCas9 Ribonucleoprotein ComplexesEfficient Genome EditingGenetic EngineeringMolecular Biology +8

Rational design of a split-Cas9 enzyme complex

Addison V. Wright, Samuel H. Sternberg, David W. Taylor, +4

Proceedings of the National Academy of Sciences

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch

Benjamin L. Oakes, Dana C. Nadler, Avi I. Flamholz, +4

Nature Biotechnology

Allosteric Crispr-cas9 SwitchEngineeringMolecular BiologyGenetic EngineeringSynthetic Biology +6

A thermostable Cas9 with increased lifetime in human plasma

Lucas B. Harrington, David Páez-Espino, Brett T. Staahl, +4

Nature Communications

Thermostable Cas9EngineeringNonthermal PlasmaCas9 ProteinImmunology +12

Oxygen sensing in yeast: Evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes

Kurt E. Kwast, Patricia V. Burke, Brett T. Staahl, +1

Proceedings of the National Academy of Sciences