Concepedia

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

Lionel Flamant, Edith Roegiers, Michael St.Pierre, Aurélie Hayez, Christiane Sterpin, Olivier De Backer, Thierry Arnould, Yves Poumay, Carine Michiels

BMC Cancer · 2012 · 94 citations · 42 references

DOIFull text

Open access

Abstract

Altogether, our results unravel a new mechanism for taxol and etoposide resistance mediated by TMEM45A. High levels of TMEM45A expression in tumors may be indicative of potential resistance to cancer therapy, making TMEM45A an interesting biomarker for resistance.

References

42

HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia

Jung‐whan Kim, Irina Tchernyshyov, Gregg L. Semenza et al. · Cell Metabolism · 2006 · 3.8K citations · Full text

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

Yixin Wang, Jan G.M. Klijn, Yi Zhang et al. · The Lancet · 2005 · 2.7K citations

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A Model-Based Background Adjustment for Oligonucleotide Expression Arrays

Zhijin Wu, Rafael A. Irizarry, Robert Gentleman et al. · Journal of the American Statistical Association · 2004 · 1.7K citations

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

Yongyu Wang, J.G.M. Klijn, Y ZHANG et al. · The Lancet · 2005 · 1.2K citations

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Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study

Marianne Nordsmark, Søren M. Bentzen, Volker Rudat et al. · Radiotherapy and Oncology · 2005 · 930 citations

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