Concepedia

p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content

Joon‐Young Park, Pingyuan Wang, Takumi Matsumoto, Ho Joong Sung, Wenzhe Ma, Jeong Won Choi, Stasia A. Anderson, Scot C. Leary, Robert S. Balaban, Ju‐Gyeong Kang,

Circulation Research · 2009 · 191 citations · 46 references

DOIFull text

Open access

Abstract

Our current findings indicate that p53 promotes aerobic metabolism and exercise capacity by using different mitochondrial genes and mechanisms in a tissue-specific manner.

References

46

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Karim Bensaad, Atsushi Tsuruta, Mary Selak et al. · Cell · 2006 · 1.9K citations · Full text

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p53 Regulates Mitochondrial Respiration

Satoaki Matoba, Ju‐Gyeong Kang, Willmar D. Patino et al. · Science · 2006 · 1.6K citations

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Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice

Nils‐Göran Larsson, Jianming Wang, Hans Wilhelmsson et al. · Nature Genetics · 1998 · 1.6K citations

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Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

Christian Frezza, Sara Cipolat, Luca Scorrano · Nature Protocols · 2007 · 1.2K citations · Full text

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Simona Parrinello, Enrique Samper, Ana Krtolica et al. · Nature Cell Biology · 2003 · 1.1K citations · Full text

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