Aluminum Phosphate Catalyzed Free Solvent Preparation of β-enamino Esters

Abstract

<b> </b>Aluminum phosphate (AlPO<SUB>4</SUB>) efficiently catalyzed the condensation of 1,3-ketoesters with primary amines under free solvent conditions. The catalyst has been prepared and characterized by powder XRD and FT-IR studies. The AlPO<SUB>4</SUB> synthesis was performed in water at room temperature from AlCl<SUB>3</SUB> and H<SUB>3</SUB>PO<SUB>4</SUB> in the presence of ammonia solution. Resultant material showed good catalytic efficiency in condensation of 1,3-ketoesters with primary amines using a domestic microwave oven with no solvent. The reaction was complete in 7 min to afford β-enamino esters in a high yield and high selectivity.